Current position:

PostDoc at the Carl von Ossietzsky University of Oldenburg, Department of Experimental Allergology and Immunodermatology

Feb. 2020 - July 2025
PhD student and research assistant at the University of Oldenburg, Department for Human Medicine, Departments of Experimental Allergology and Immunodermatology & Anatomy

Academic education and scientific career:

2018 - 2019
Master's programme "Molecular Medicine" at Trinity College Dublin

Master's thesis at the Trinity Biomedical Sciences Institute, Dublin

Testing the efficacy of therapeutic interventions in models of fatty liver diseases.

2015 - 2018
Bachelor's degree programme in "Molecular and Technical Medicine" at Furtwangen University, Villingen-Schwenningen

Bachelor's thesis at the University of Vienna, Department of Nutritional Sciences

Investigation of the influence of supplementation of a short-chain fatty acid on the development of alcohol-related liver disease in a model organism

School education:

2006 - 2013
General higher education entrance qualification at Schickhardt-Gymnasium, Herrenberg

Current position

Carl von Ossietzky University of Oldenburg, Department of Health Services Research, Division of Assistance Systems and Medical Technology

2022 - 2025

Doctoral candidate and research assistant at the University of Oldenburg, Department of Health Services Research, Division of Assistance Systems and Medical Technology

Academic education and scientific career

2019-2022
Master's degree programme in Computing Science at the University of Oldenburg

Master's thesis topic: Induction of emotional stress from the intensive care context with storytelling in VR

2015-2019
Bachelor's degree in Computing Science with Physics as an application subject at the University of Oldenburg

Bachelor's thesis topic: Implementation of multimodal alarms on augmented reality glasses for noise reduction in intensive care units

School education

2007-2015
General higher education entrance qualification at the KGS Schwanewede

2018 - 2024
Doctoral candidate and research assistant at the University of Oldenburg

Education:

2014 - 2017
Master of Medicine (Biomedical engineering): Jilin University School of Pharmaceutical Sciences, Changchun, China

2010 - 2014
Bachelor of Engineering (Bio-pharmaceuticals): Zhuhai College of Jilin University, Zhuhai, China

Research work:

2014 - 2015
Course studies at Jilin University

2015 - 2017
Cooperation research programme at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.
Graduate issue:
Generation of Larger Teeth from Human iPS Cells with Pig Dental Mesenchyme.

Chen Y, Bräuer AU, Koch KW. (2022) Retinal degeneration protein 3 controls membrane guanylate cyclase activities in brain tissue. Front Mol Neurosci . 2022 Dec 21;15:1076430. doi: 10.3389/fnmol.2022.1076430. eCollection 2022.

Jia B, Huang L, Chen Y, Liu S, Chen C, Xiong K, Song L, Zhou Y, Yang X, Zhong M. A novel contiguous deletion involving NDP, MAOB and EFHC2 gene in a patient with familial Norrie disease: bilateral blindness and leucocoria without other deficits. J Genet. 2017 Dec;96(6):1015-1020.

Yang Y, Zhao Y, Liu X, Chen Y, Liu P*, Zhao L. Effect of SOX2 on odontoblast differentiation of dental pulp stem cells. Mol Med Rep. 2017 Oct 17; 10.3892

Zhao L, Feng Y, Chen X, Yuan J, Liu X, Chen Y, Zhao Y, Liu P*, Li Y. Effects of IGF-1 on neural differentiation of human umbilical cord derived mesenchymal stem cells. Life Sci. 2016 Apr 15;151:93-101.

Liu P, Feng Y, Dong D, Liu X, Chen Y, Wang Y, Zhou Y*. Enhanced renoprotective effect of IGF-1 modified human umbilical cord-derived mesenchymal stem cells on gentamicin-induced acute kidney injury. Sci Rep. 2016 Feb 2; 6:20287.

Liu P, Cai J, Dong D, Chen Y, Liu X, Wang Y, Zhou Y*. Effects of SOX2 on Proliferation, Migration and Adhesion of Human Dental Pulp Stem Cells. PLoS One. 2015 Oct 23;10(10).

Current position

Friedrich-Alexander-University Erlangen-Nuremberg

2020 - 12/2022
Research assistant in the Department of Anatomy in the Department for Human Medicine at the University of Oldenburg

Academic training and scientific career

2001 - 2006
Research Assistant at the Institute of Anatomy at the School of Medicine in Magdeburg

1999 - 2001
Research Assistant at the Institute for Medical Psychology at the School of Medicine in Magdeburg

1996 - 1999
Research Assistant at the Institute of Anatomy at the Hannover Medical School

1995 - 1996
Research Assistant at the Institute of Anatomy at the School of Medicine in Frankfurt a.M.

1993 - 1994
Research assistant in the Department of Zoophysiology at the University of Oldenburg

1990 - 1993
Scholarship holder of the State of Lower Saxony as a doctoral candidate in the Department of Zoophysiology at the University of Oldenburg

PhD topic:
Localisation, characterisation and isolation of the opiate receptor in crustaceans
Evaluation: summa cum laude

1985 - 1990
Studied Biology at the University of Oldenburg, Grade Point Average: 1.0
Diploma topic:
Autoradiographic and immunocytochemical investigations of ultramicroscopic structures of the neuroendocrine system of crustaceans

1. Wickramasekaraa, Rochelle N.; Bockman, Charles; Hanke, Joachim; Schwegler, Herbert; McGeed, JoAnn; Walsh, Edward; Yilmazer-Hanke, Deniz. (2020). Alpha2-adrenergic dysregulation in congenic DxH recombinant inbred mice selectively bred for a high fear-sensitised (H-FSS) startle response. Pharmacology, Biochemistry and Behaviour. 188. 172835
   
2. Yilmazer-Hanke, Deniz; Eliava, Marina; Hanke, Joachim; Schwegler, Herbert; Asan, Esther. (2016). Density of Acetylcholine Esterase (AchE) and Tyrosine Hydroxylase (TH) Containing Fibers in the Amygdala of Roman High- and Low-Avoidance Rats. Neuroscience letters. 632. 114-8.
   
3. Browne, Caroline; Hanke, Joachim; Rose, Claudia; Walsh, Irene; Foley, Tara; Clarke, Gerard;Schwegler, Herbert; Cryan, John; Yilmazer-Hanke, Deniz. (2014). Effect of Acute Swim Stress on Plasma Corticosterone and Brain Monoamine Levels in Bidirectionally Selected DxH Recombinant Inbred Mouse Strains Differing in Fear Recall and Extinction. Stress (Amsterdam, Netherlands). 17. 1-36.
   
4. Browne, Caroline; Clarke, Gerard; Hanke, Joachim; G Dinan, Timothy; Schwegler, Herbert; Yilmazer-Hanke, Deniz; Cryan, John. (2013). Alterations in prefrontal cortical serotonin and antidepressant-like behaviour in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain. Behavioural brain research. 236. 283-8.
   
5. Rose, Claudia; Schwegler, Herbert; Hanke, Joachim; Yilmazer-Hanke, Deniz. (2012). Pregnancy rates, prenatal and postnatal survival of offspring, and litter sizes after reciprocal embryo transfer in DBA/2JHd, C3H/HeNCrl and NMRI mice. Theriogenology. 77. 1883-93.
   
6. Frisch, Christian; Hanke, Joachim; Kleinerüschkamp, Sven; Roeske, Sandra; Kaaden, Sabine; Elger, Christian; Schramm, Johannes; Yilmazer-Hanke, Deniz; Helmstaedter, Christoph. (2009). Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients. Biological psychiatry. 66. 433-40.
   
7. Rose, Claudia; Röhl, Friedrich-Wilhelm; Hanke, Joachim; Schwegler, Herbert; Yilmazer-Hanke, Deniz. (2008). Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitisation in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer. Behaviour genetics. 38. 596-611.
   
8. Rose, Claudia; Schwegler, Herbert; Hanke, Joachim; Röhl, Friedrich-Wilhelm; Yilmazer-Hanke, Deniz. (2006). Differential effects of embryo transfer and maternal factors on anxiety-related behaviour and numbers of neuropeptide Y (NPY) and parvalbumin (PARV) containing neurons in the amygdala of inbred C3H/HeN and DBA/2J mice. Behavioural brain research. 173. 163-8.
   
9. Rose, Claudia; Röhl, Friedrich-Wilhelm; Schwegler, Herbert; Hanke, Joachim; Yilmazer-Hanke, Deniz. (2006). Maternal and Genetic Effects on Anxiety-Related Behaviour of C3H/HeN, DBA/2J and NMRI Mice in a Motility-Box Following Blastocyst Transfer. Behaviour genetics. 36. 745-62.
   
10. Roskoden, Thomas; Hanke, Joachim; Yilmazer-Hanke, Deniz; Schwegler, Herbert. (2005). Reduced number of CRF-containing neurons in the central amygdala correlated with enhanced locomotor activity following early postnatal corticosterone treatment in the Wistar rat. Behavioural brain research. 165. 221-8.
    
11. Yilmazer-Hanke, Deniz; Hantsch, M; Hanke, Joachim; Schulz, Carla; Faber-Zuschratter, Heidi; Schwegler, Herbert. (2004). Neonatal thyroxine treatment: Changes in the number of corticotropinreleasing-factor (CRF) and neuropeptide Y (NPY) containing neurons and density of tyrosine hydroxylase positive fibres (TH) in the amygdala correlate with anxiety-related behaviour of Wistar rats. Neuroscience. 124. 283-97.
    
12. Hanke, Joachim; Sabel, Bernhard. (2004). L-type calcium channel antagonist nifedipine reduces neurofilament restitution following traumatic optic nerve injury. Acta neurochirurgica. Supplement. 89. 75-80.
    
13. Hanke, Joachim; Sabel, Bernhard. (2002). Anatomical correlations of intrinsic axon repair after partial optic nerve crush in rats. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomical Society. 184. 113-23.
    
14. Hanke Joachim (2001): Apoptosis in cultured islets of Langerhans and occurrence of Bcl-2, Bak, Bax, Fas and FasL. Cell Tissues Organs 169: 113-124.
    
15. Hanke Joachim (2000) Apoptosis and occurrence of Bcl-2, Bak, Bax, Fas and FasL in the developing and adult rat endocrine pancreas. Anat Embryol 202: 303-312.
    
16. Yilmazer-Hanke D, Hanke J (1999): Progression of Alzheimer-related neuritic plaque pathology in the entorhinal region, perirhinal cortex, and hippocampal formation. Dement Geriatr Cogn Disord 10: 70-76.
    
17. Nagy Z, Yilmazer DM, Braak H, Braak E, Schultz C, Hanke J (1998): Assessment of the pathological stages of Alzheimer's disease in thin paraffin sections: A comparative study. Dement Geriatr Cogn Disord 9: 140-144.
    
18. Nagy Z, Vatter-Bittner B, Braak H, Braak E, Yilmazer DM, Schultz C, Hanke J (1997): Staging of Alzheimer-type pathology: An interrater-intrarater study. Dement Geriatr Cogn Disord 8: 248-251.
    
19. Hanke J, Yilmazer-Hanke DM (1997): Pigmentarchitectonic subfields of the entorhinal region as revealed in tangential sections. J Brain Res 38: 427-432.
    
20. Hanke J, Yilmazer-Hanke DM (1997): Variabilities in the distribution of neurofibrillary tangles in the anterior parahippocampal gyrus at initial stages of Alzheimer's disease. Clin. Neuropathol 16: 299-302.
    
21. Hanke J (1997): Sulcal pattern of the anterior parahippocampal gyrus in the human adult. Ann Anat 179: 335-339.
    
22. Hanke J, Willig A, Yinon U, Jaros PP (1997): Delta and kappa opioid receptors in eyestalk ganglia of a crustacean. Brain Res. 744: 279-284.
    
23. Hanke J, Willig A, Jaros PP (1996): Opioid receptor types for endogenous enkephalin in the thoracic ganglion of the crab, Carcinus maenas. Peptides 17: 965-972.
    
24. Hanke J, Jaros PP, Willig A (1993): Ultrastructural autoradiographic localisation of opiod receptors on membranes with CHH immunogold detected axon terminals in a neurohemalorgan of Carcinus maenas L.. Histochem. 99: 405-410.
    
25. Hanke J, Jaros PP, Willig A (1992): Differential localisation of leu-enkephalin in axon terminals of the sinus gland of the crabs Carcinus maenas L., Eriocheir sinensis and Uca pugilator. Cell Tissue Res. 270: 521-526.

1 Sakr F, Dyrba M, Bräuer AU, Teipel S (2021). Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer's Disease. J Alzheimers Dis. 2021 Dec 9. doi: 10.3233/JAD-201504.

1 Gross I, Tschigor T, Salman AL, Yang F, Luo J, Vonk D, Hipp MS, Neidhardt J, Bräuer AU (2021).
A systematic expression analysis of Plasticity-Related Genes in mouse brain development brings PRG4 into play. Dev Dyn. 2021 Oct 7. doi: 10.1002/dvdy.428. Online ahead of print. PMID: 34622503.

2 Gross I, Bräuer AU. Modulation of LPA Receptor Activity: the key to successful neural regeneration? Neural Regen Res, 2020 15(1):53-54

3 Brand I, Gross I, Li D, Zhang Y, Bräuer AU. Pneumatic conveying printing technique for bioprinting applications. RSCAdv., 2019, 9, 40910: DOI: 10.1039/c9ra07521f

4. Suckau O.*, Gross I.*, Schrötter S., Yang F., Luo J., Wree A., Chun J., Baska D., Baumgart J., Kano K., Aoki J., Bräuer AU. _LPA1, _LPA2, _LPA4, and _LPA6 receptor expression during mouse brain development. Developmental Dynamics, 2019 Mar 8

Current position

Senior Researcher, Charité University Medicine Berlin

2020 - 8/2021
Research assistant for habilitation in the Department for Human Medicine at the University of Oldenburg

Academic education and scientific career

2016 - 2019
Research assistant (postdoctoral fellow) at the Institute of Cell and Neurobiology, Centre for Anatomy, Charité - Universitätsmedizin Berlin

2011 - 2016
Research Associate (Postdoctoral Researcher) at the Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin

2007 - 2011
Research assistant (doctoral candidate) at the Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin

PhD topic:
Molecular profiling of the haematopoietic support of interleukin-stimulated endothelial cells

Evaluation: magna cum laude

2004-2006
Research Trainee at the Institute for Transfusion Medicine, Charité-Universitätsmedizin Berlin

Topic: The role of B-cell activating factor (BAFF) in immune thrombocytopenia

1998-2001
Biomedical scientist at the Laboratory of Clinical Biochemistry, Cerrahpaşa School of Medicine, Istanbul University

1999-2001
Studies M.Sc. Biology, Gebze Institute of Technology, Turkey

1994-1998
B.Sc. in Biomedical Sciences, Cerrahpaşa School of Medicine, Istanbul University

1. Bal, G*; Depré F*, Dzamashvili M, Ringel F, Salama A. Effect of thrombopoietin receptor agonists on leucocyte and haematopoietic stem and progenitor cell in peripheral blood of patients with immune thrombocytopenia. Annals of Hematology, 2017.

2. Cecilia B, Seval T, Ulrich R, Lars F, Bal G, Schulz CO, Hemmati P, Renate A, Hanno R, Philipp le C. A Rare Case of Acute Myeloid Leukemia with a t(2;3) Chromosomal Translocation Characterised by Thrombophilia and Chemoresistance. J Clin Exp Hematop. 2016.

3. Kohn B., Bal G., Chirek A., Rehbein S., Salama A. Romiplostim treatment in dogs as a natural animal model for refractory immune thrombocytopenia. BMC Veterinary Research (2016).

4. Bal G, Salama, A at all, Identification of novel biomarkers in chronic immune thrombocytopenia (ITP) by microarray-based serum protein profiling. Br J Haematol. (2015).

5. Kamhieh-Milz J, Moftah RF, Bal G, Futschik M, Sterzer V, Khorramshahi O, Burow M, Thiel G, Stuke-Sontheimer A, Chaoui R, Kamhieh-Milz S, Salama A. Differentially expressed microRNAs in maternal plasma for the noninvasive prenatal diagnosis of Down syndrome (trisomy 21). Biomed Res Int. (2014)

6. Bal G, Kamhieh-Milz J, Sterzer V, Al-Samman M, Debski J, Klein O, Kamhieh-Milz S, Bhakdi S, Salama, A. Proteomic profiling of secreted proteins for the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells. Cell Transplant. (2012).

7. Kamhieh-Milz J, Bal G, Sterzer V, Kamhieh-Milz S, Arbach O, Salama A. Reduced antioxidant capacities in platelets from patients with autoimmune thrombocytopenia purpura (ITP) Platelets (2012).

8. Bal G, Kamhieh-Milz J, Futschik M, Haupl T, Salama A, Moldenhauer A. Transcriptional profiling of the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells (HUVECs). Cell Transplant. (2011).

9. Moldenhauer A, Futschik M, Lu H, Helmig M, Götze P, Bal G, Zenke M, Han W,Salama A. Interleukin 32 promotes hematopoietic progenitor expansion and attenuates bone marrow cytotoxicity. Eur J Immunol. (2011).

10. Moldenhauer A, Genter G, Lun A, Bal G, Kiesewetter H, Salama A. Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors. BMC Immunol. (2008).

11. Emmerich F*, Bal G*, Barakat A, Milz J, Mühle C, Martinez-Gamboa L, Dörner T, Salama A. High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura. Br J Haematol. (2007).

Current position

Scientist QC
Lonza AG Visp, Switzerland

Academic training and scientific career

2017 - 2021
PhD student at the University of Oldenburg, Department for Human Medicine, Department of Anatomy

2015 - 2017
PhD student at the Rostock University Medical Centre, Institute of Anatomy, Molecular Neurobiology Group

PhD topic: Analysis of lipid metabolism changes in NPC1 mouse model with different treatment strategies

2014 - 2017
Research assistant at the Rostock University Medical Centre, Institute of Anatomy

2006 - 2012
Study of Biosciences at the University of Rostock
Diploma thesis at the Albrecht-Kossel Institute for Neuroregeneration, Rostock
Topic of the diploma thesis: Investigations on the activity enhancement of alpha-galactosidase A using potential modifier genes

School education

2003 - 2006
General higher education entrance qualification at the vocational grammar school in Oelsnitz/Erzgebirge,
Specialisation: Information and communication technology

1. Gläser A, Hammerl F, Gräler MH, Coldewey SM, Völkner C, Frech MJ, Yang F, Luo J, Tönnies E, von Bohlen Und Halbach O, Brandt N, Heimes D, Neßlauer AM, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Bräuer AU. Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int J Mol Sci. 2020 Jun 24;21(12):E4502. doi: 10.3390/ijms21124502.

2 Feng X, Yang F, Rabenstein M, Wang Z, Frech M, Wree A, Bräuer AU, Witt M., Gläser A., Hermann A., Rolfs A, Luo J, Stimulation of mGluR1/5 improves defective internalisation of AMPA receptors in NPC1 mutant mouse, Cerebral Cortex, 2019, Oct 10

3. Neßlauer A-M., Gläser A., Gräler M., Engelmann R., Müller-Hilke B., Frank M., Burstein C., Rolfs A., Wree A., Witt M., Bräuer AU. A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-Pick Disease Type C1. Lipids Health Dis., 2019 June, 18:146

4 Meyer A,*, Gläser A.*, Bräuer AU., Wree A., Strotmann J., Rolfs A., Witt M. Olfactory performance as an indicator for protective treatment effects in an animal model of neurodegeneration, Front. Integr. Neurosci. 2018 Aug. 12;12:35

5 Ebner L., Gläser A., Bräuer AU., Witt M., Wree A., Rolfs A., Frank M., Vollmar B., Kuhla A. Evaluation of Two Liver Treatment Strategies in a Mouse Model of Niemann-Pick-Disease Type C1, Int. J. Mol. Sci., 2018 Mar, 19 (4): 972

6 Reetz J., Hildebrandt S., Schmidt A., Meier C., Herchenroder O., Gläser A., Witt M., Pützer BM., Wree A., Novel subventricular zone early progenitor cell-specific adenovirus for in vivo therapy of central nervous system disorders reinforces brain stem cell heterogeneity, Brain structure & function, 2015 May, 221 (4): 2049-59

7 Lukas J., Pockrandt A., Seemann S., Sharif M., Runge F., Pohlers S., Zheng C., Gläser A., Beller M., Rolfs A., Giese A., Enzyme Enhancers for the treatment of Fabry and Pompe Disease, Molecular Therapy , 2015 Mar, 23 (3): 456-464

*Contributed equally as first author.

July 2018 - June 2020
Research assistant in the Department of Anatomy in the Department of Human Medicine at the University of Oldenburg

Academic career

2011 - 2018
Research assistant at the Institute for Brain Research at the University of Bremen in the working group of Prof Ursula Dicke and Prof Gerhard Roth.

Research projects included studies on the functional anatomy of neuronal connectivity in the diencephalon and mesencephalon in amphibians involved in focussed visual attention.

Co-operation with Jannek von Byern (Vienna) on the topic of skin glands and skin secretions of salamanders (see publication list).

2004 - 2010
Studied biology, majoring in zoology and minoring in botany and ecology

1992 - 1995
Studied human medicine at the MLU in Halle / Saale

Memberships

VBIO Association of German Biologists
GDNÄ Society of German Natural Scientists and Physicians
DGGTB German Society for the History and Theory of Biology

Special specialisations and interests

• Comparative anatomy of vertebrates including humans
• Anatomical variants
• Anatomical collections - historical and current significance

1. von Byern J, Mebs D, Heiss E, Dicke U, Wetjen O, Bakkegard K, Grunwald I, Wolbank S, Mühleder S, Gugerell A, Fuchs H, Nürnberger S. Salamanders on the bench - A biocompatibility study of salamander skin secretions in cell cultures. Toxicon. 2017 Sep 1;135:24-32. doi: 10.1016/j.toxicon.2017.05.02 Epub 2017 May 25

2. von Byern J, Grunwald I, Kosok M, Saporito RA, Dicke U, Wetjen O, Thiel K, Borcherding K, Kowalik T, Marchetti-Deschmann M. Chemical characterisation of the adhesive secretions of the salamander Plethodon shermani (Caudata, Plethodontidae). Sci Rep. 2017 Jul 27;7(1):6647. doi: 10.1038/s41598-017-05473-z.